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ea0089c33 | Clinical – Surgery/Applied Pathology | NANETS2022

High-Grade Pancreatic Neuroendocrine Neoplasms: Interobserver Diagnostic Accuracy and Relationship with Clinicopathological and Molecular Characteristics

Taherian, MD Mehran , Waters, MD Rebecca , Foo, MD Wai Chin , Maru, MD Dipen , Abraham, MD Susan C. , Rashid, MBBS, PhD Asif , Wang, MD, PhD Huamin , Wei, MD Dongguang , Taggart, MD Melissa W. , Chatterjee, MD Deyali

Background: The pathogenesis, biologic behavior, and treatment of well-differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC) are different. The diagnosis relies on multiple factors, but pathologic assessment is crucial. Based on currently available diagnostic criteria, the distinction between NET G3 and NEC are made on morphologic assessment, without taking Ki-67 proliferative index into consideration. This study looks at the conc...

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High-Grade Pancreatic Neuroendocrine Neoplasms: Interobserver Diagnostic Accuracy and Relationship with Clinicopathological and Molecular Characteristics

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